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The Martha Jefferson Hospital Area Neighborhoods are located in the northeastern section of the city, in close proximity to the Downtown Mall. For the purpose of the Comprehensive Plan, the neighborhood is bounded by the 250 Bypass to the north and generally by 9th Street to the west. East High Street, Meade Avenue and East Market Street form the eastern and southern edges of the neighborhood. Within the plan area there are several identifiable and distinct neighborhoods. The Martha Jefferson Area Neighborhood Association (MJANA) area is concentrated immediately around the Martha Jefferson Hospital and includes the Locust and Lexington areas as well as areas to the west of the hospital. The Little High Street area is a distinct neighborhood area located south of High Street and West of 10th Street. The Burnley Moran Area is located east of Locust Avenue and is defined by Burnley Moran Elementary School. Each of these neighborhood areas is being considered together as a part of this Martha Jefferson Areas Neighborhood Plan.

The Martha Jefferson Hospital is the major center of activity and employment in the plan area, which generates some related uses in the neighborhood, including a number of doctor's offices. Historic Maplewood Cemetery is located just to the west of the plan area but within the MJANA area, with graves dating from the 1840's. Taylor Walk at the Martha Jefferson Hospital commemorates Fairfax Taylor, the first African American property owner in the area. Fairfax Taylor and his family lived in the neighborhood during the mid 19th Century.

Located in the southern portion of the plan area is "The Farm," a historic house, which dates from 1825. The southeastern section of the plan area was developed out of the subdivision of the original estate that was "The Farm." Locust Grove is an historic structure located at 810 Locust Avenue. The house was built c. 1840 on a 500 acre subdivision of "The Farm." The Locust Grove property was bought in the 1870's and subdivided The subdivision of Locust Grove formed a portion of the neighborhood north of High Street. High Street is a commercial corridor in the plan area, and both East High Street and Locust Avenue are entranceways into Downtown Charlottesville. The human scale and variety of the architecture contribute to the charm of the Martha Jefferson area neighborhoods.